These studies demonstrate that CD8+ Tregs can be induced in a range of different systems and exhibit different phenotypes and functions. IL-10 takes on a pivotal part in controlling swelling by suppressing APC function and inflammatory cytokine production (28). requirement for CD4+ T cell help, the dependence on IL-2/CD25 and CD40-CD40L pathways, and the ability … Continue reading These studies demonstrate that CD8+ Tregs can be induced in a range of different systems and exhibit different phenotypes and functions